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The Value of Diagnostic Information to Patients with Suspected Multiple Sclerosis
Arch Neurol 51:67-72, Mushlin,A.I.,et al, 1994
See this aricle in Pubmed

Article Abstract
Those in whom no definitive diagnosis emerged tend to be more anxious rather than being reassured by the"negative"workup.Individuals with" positive"workups became less anxious and expressed favorable feelings about the diagnostic workup even though they often faced a chronic disease.Overall,the diagnostic workup seemed to benefit patients and improve their sense of well-being.However,whether the effects were beneficial or not depended on the results of the diagnostic workup itself. In clinical practice the decision to undergo testing in situations in which definitive treatment is unavailable should be individualized.The potential for negative as well as positive consequences should be recognized.
 
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